2025

• W. Zou#, S. Deng#, X. Chen#, J. Ruan#, H. Wang, W. Zhan, J. Wang, Z. Liu, Z. Yan*. TMEM63B functions as a mammalian hyperosmolar sensor for thirst. Neuron, 2025.

• S.Fu#, X. Pan#, M. Lu#, J. Dong, Z. Yan*. Human TMC1 and TMC2 are mechanically gated ion channels. Neuron, 2025.

 

2024​

• Y. Zhang#, Y. Xue#, Y. Ma, X. Du, B. Lu*, Y. Wang*, Z. Yan*. Improved classification and pathogenicity assessment by comprehensive functional studies in a large data set of KCNQ2 variants. Life Sciences, 2024, 339, 122378​

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2022

• H. Zheng#, X. Yan#, G. Li, H. Lin, S. Deng, W. Zhuang, F. Yao, Y. Lu, X. Xia, H. Yuan, L. Jin, Z. Yan*. Proactive functional classification of all possible missense single-nucleotide variants in KCNQ4. Genome Research, 2022, 32: 1573-1584.

• S. Li, B. Li, L. Gao, J. Wang, Z. Yan*. Humidity response in Drosophila olfactory sensory neurons requires the mechanosensitive channel TMEM63. Nature Communications, 2022, 13(1): 3814.

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2021

• B. Li#, S. Li#, H. Zheng, Z. Yan*. Nanchung and Inactive define pore properties of the native auditory transduction channel in Drosophila. Proc Natl Acad Sci USA, 2021,118 (49) e2106459118.

• Y. Wang#, Y. Guo#, G. Li, C. Liu, L. Wang, A. Zhang, Z. Yan*, C. Song*. The Push-to-Open Mechanism of the Tethered Mechanosensitive Ion Channel NompC. eLife, 2021,10:e58388.

• W. Zhuang, Z. Yan*. The S2-S3 Loop of Kv7.4 Channels Is Essential for Calmodulin Regulation of Channel Activation, Frontiers in Physiology, 2021, 11:604134.

• B. Li, S. Li, Z. Yan*. Axonemal Dynein DNAH5 is Required for Sound Sensation in Drosophila Larvae. Neuroscience Bulletin, 2021.

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2020

• Y. Jia#, Y. Zhao#, T. Kusakizako#, Y. Wang, C. Pan, Y. Zhang, O. Nureki*, M. Hattori*, Z. Yan*. TMC1 and TMC2 proteins are pore-forming subunits of mechanosensitive ion channels. Neuron, 2020, 105, 310–321.

• X. Xia, Q. Zhang*, Y. Jia, Y. Shu, J. Yang, H. Yang, Z. Yan*. Molecular basis and restoration of function deficiencies of Kv7.4 variants associated with inherited hearing loss, Hearing Research, 2020, 388.

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2018

• M. Zhang, D. Wang, Y. Kang, J.X. Wu, F. Yao, C. Pan, Z. Yan*, C. Song*, L. Chen*. Structure of the mechanosensitive OSCA channels. Nature Structural & Molecular Biology, 2018, 25, 850–858. 

• M. Zhang#, X. Li#, H. Zheng, X. Wen, S. Chen, J. Ye, S. Tang, F. Yao, Y. Li*, Z. Yan*. Brv1 is required for Drosophila larvae to sense gentle touch. Cell Reports, 2018, 23, 23-31.

• Y. Sun, Y. Jia, Y. Guo, F. Chen*, Z. Yan*. Taurine transporter dEAAT2 is required for auditory transduction in Drosophila. Neuroscience Bulletin, 2018, 34(6), 939–950. 

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2017

• A. Tomita#, M. Zhang#, F. Jin#, W. Zhuang, H. Takeda, T. Maruyama, M. Osawa, K. Hashimoto, H. Kawasaki, K. Ito, N. Dohmae, R. Ishitani, I. Shimada, Z. Yan*, M. Hattori* & O. Nureki*. ATP-dependent modulation of MgtE in Mg2+ homeostasis. Nature Communications, 2017, 8, 148.

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2014​

• W. Zhang#, Z. Yan#, B. Li, L.Y. Jan, Y. N. Jan*. Identification of motor neurons and a mechanosensitive sensory neuron in the defecation circuitry of Drosophila larvae. eLife, 2014, 3, e03293.

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2013

• Z. Yan#, W. Zhang#, Y. He, D. Gorczyca, Y. Xiang, L.E. Cheng, S. Meltzer, L.Y. Jan, Y. N. Jan*. Drosophila NompC is a mechanotransduction channel subunit for gentle touch sensation. Nature, 2013, 493, 221–5.

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2008

• Z. Yan, J. Tan, C. Qin, Y. Lu, C. Ding, M. Luo*. Precise circuitry links bilaterally symmetric olfactory maps. Neuron, 2008, 58, 613–24.

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